エクセルデータを読んじゃう。

DATASはシート名ね。
さらにファイルにはASPNETさんの読み取り可能な権限を付加してあげてくださいね。

Sub Page_Load(Sender As Object, E As EventArgs)

    ' TODO: ConnectionStringとCommandTextの値を調整してください


    Dim ConnectionString As String = "Provider=Microsoft.Jet.OLEDB.4.0;" + _
        "Data Source=%mydbq%;Extended Properties=""Excel 8.0;HDR=Yes;IMEX=1"""
    Dim CommandText As String = "SELECT * FROM [DATAS$]"

    ConnectionString=replace(ConnectionString,"%mydbq%","c:\コピーmyfile.XLS")

    Dim myConnection As New System.Data.OleDb.oledbConnection(ConnectionString)
    Dim myCommand As New System.Data.OleDb.oledbCommand(CommandText, myConnection)

    myConnection.Open()

    DataGrid1.DataSource = myCommand.ExecuteReader(CommandBehavior.CloseConnection)
    DataGrid1.DataBind()

End Sub